Gum Disease Is Associated With Elevated Levels Of C-Reactive Protein And Fibrinogen And It May Be A Coronary Heart Disease Risk Factor

December, 2002
BMC Infectious Diseases

Effect of treating periodontitis on C-reactive
protein levels:a pilot study

By Kimmo Mattila, Marja Vesanen, Ville Valtonen, Markku Nieminen1, Timo Palosuo, Vesa Rasi, and Sirkka Asikainen

BACKGROUND:
Periodontitis is associated with elevated levels of C-reactive protein and fibrinogen and it may be a coronary heart disease risk factor. We wanted to study if treatment of periodontitis can decrease the levels of these inflammatory markers.

METHODS:
C-reactive protein and fibrinogen levels were measured in 35 patients (21 M, 14 F, mean age 50 years) with adult periodontitis, before and after treatment.

RESULTS:
The median baseline C-reactive protein level in the patients was 1.05 mg/l and it decreased to 0.7 mg/l (p = 0.05) after periodontal treatment. Of the 30 patients who could be included in the analyses, 24 patients had a baseline level below 2 mg/l (the 95th percentile limit in Finland); 6 patients had levels higher than this. Elevation of the baseline C-reactive protein level or the magnitude of its decrease were not associated with severe form of periodontitis. The decrease in C-reactive protein levels was at least 50 % in 4/6 of those with elevated baseline levels, as compared with 3/24 of the rest of the patients (p = 0.016). No corresponding effect was observed in fibrinogen levels.

CONCLUSIONS:
Periodontitis seems to increase C-reactive protein only in some individuals, presumably the ones reacting to it with a systemic inflammatory reaction. Periodontal treatment decreases C-reactive protein levels in these individuals and it may thus decrease their risk of coronary heart disease.